The vNN-ADMET webserver is a publicly available online platform to predict absorption, distribution, metabolism, excretion, and toxicity (ADMET) properties and to build new models based on our variable nearest neighbor (vNN) methodology. We have developed 15 ADMET prediction models to quickly, and with high confidence assess some of the most important properties, such as cytotoxicity, mutagenicity, cardiotoxicity, drug-drug interactions, microsomal stability, and drug-induced liver injury.